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NRSC 500

Module Three





Oct. 23
8:30-10:30

Secondary Messengers I: Cyclic Nucleotides
Dr. Steve Vincent

 

 

Reading:

Lecture Notes (2010)

Pierce, K.L., Premont, R.T. and Lefkowitz, R.J. (2002) Seven-Transmembrane Receptors. Nature Reviews in Molecular Cell Biology 3: 639-650.

  • cAMP and the concept of intracellular second messengers
  • discovery of G proteins - activation of adenylyl cyclase
  • the family of G protein-coupled receptors
  • G proteins as molecular switches and timers
  • roles for βγ subunits
  • actions of cAMP - PKA




Oct. 25
8:30-10:30

Lipids in Brain Structure and Signaling
Dr. Cheryl Wellington

 

 

Reading:

Lecture Notes (of 2012)




Oct. 28
8:30-10:30

Secondary Messengers II: Ca++ and IP3
Dr. Brian MacVicar

 

 

Reading:

Lecture Notes (of 2011)

Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nature Reviews in Molecular Cell Biology 1: 11-21, 2000.

Gu and Spitzer, Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients.
Nature 375: 784-787, 1995.

  • IP3 and DAG production and actions and metabolism
  • IP3 and ryanodine receptors
  • cADP-ribose, production and action
  • Targets for the actions of calcium (calmodulin, calcineurin etc.)
  • Calcium waves, calcium oscillations
  • The AM and FM of calcium signalling (with neuro examples)





Oct. 30
8:30-10:30

Genetic resources and approaches
Dr. Robert Holt Dr. Paul Pavlidis

 

 

Reading:

PPT Presentation 1 (Pavlidis)

PPT Presentation 2 (Holt)

Web Resources:

NCBI: The Mother of all Web Resources
http://www.ncbi.nlm.nih.gov

Gene Discovery Page - a guide on how to figure out what genes may do
http://www.biosino.org/mirror/
         bioinformatics.weizmann.ac.il/gdp/index.html

DNA Microarrays: Whys and wherefores of Gene chips
http://www.deathstarinc.com/science/biology/chips.html

Jackson Labs - Mouse informatics/gene expression
http://www.informatics.jax.org

OMIM- Human Genetic Disorders: Every mapped human disease gene and what it does
http://www.ncbi.nlm.nih.gov/omim

The Human Genome Project: What it is, where it came from, what it tells us
http://www.ornl.gov/sci/techresources/
         Human_Genome/publicat/primer/index.shtml

  • Identifying genes responsible for disease/ a specific function
  • Protein modification and the search for interacting proteins
  • model organisms and mice - what we can learn from them
  • The Human Genome Project and what we can learn from it
  • Gene Expression technologies, from SAGE to DNA chips and beyond.




Nov. 1
8:30-10:30

Receptor regulation
Dr. Lynn Raymond Dr. Steve Vincent

 

 

Reading:

Lecture Notes (updated 2013)

Luttrell LM, Gesty-Palmer D. Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacological Reviews 62:305-30, 2010.

Vithlani M, Terunuma M, Moss SJ. The Dynamic Modulation of GABAA Receptor Trafficking and its Role in Regulating the Plasticity of Inhibitory Synapses. Physiol. Rev. 91: 1009-1022, 2011.

Lu W, Roche KW. Posttranslational regulation of AMPA receptor trafficking and functionCurr. Opin. Neurobiol. 22: 470-479, 2011.

Lau CG, Zukin RS. NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders.Nat. Rev. Neurosci. 8: 413-426, 2007.
 

  • Ligand-gated ion channel regulation
    • Homologous and heterologous regulation
    • Molecular mechanisms, including changes in desensitization, peak amplitude and numbers of available receptors
    • G-protein coupled receptor regulation
    • Homologous and heterologous regulation
    • Desensitization
      • G-protein coupled receptor kinases (GRKs)
      • Arrestins
      • PKA, PKC
      • Palmitoylation
      • Receptor endocytosis
    • Downregulation
      • Receptor degradation
      • Decreased synthesis




Nov. 4
8:30-10:30

Epigenetics
Dr. Michael Kobor

 

 

Reading:

Presentation (updated 2013)

  • Epigenetic Variation in Human Health and Disease




Nov. 6
8:30-10:30

Non-Selective Cation Channels
Dr. Brian MacVicar

 

 

Reading:

Presentation (of 2010)




Nov. 8
8:30-10:30

Control of Neural Gene Expression
Dr. Weihong Song

 

 

Reading:

Bito H, Deisseroth K, and Tsien RW (1997),
Ca2+-dependent regulation in neuronal gene expression. Curr Opin Neurobiol 7:419-429.

Alberts et al., Molecular Biology of the Cell, Chapter 9, 409-469.

  • Basic transcription machinery
  • Mechanisms of regulated gene expression
  • Families of transcription factors
  • cAMP response element
  • Immediate early genes
    • Steriod receptor family
    • Homeoboxes




Nov. 15
8:30-10:30

Prions, Protein Folding and Misfolding
Dr. Neil Cashman

 

 

Reading:

Prion_Disease

Protein Misfolding Diseases




Nov. 18
8:30-10:30

Student Presentations & Review III
Dr. Steve Vincent Dr. Weihong Song

 

 







 

 

 

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NRSC 500

NRSC 501

CPSC 532
(formerly
MECH 550)

STAT 540

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