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NRSC 500

Module One




Sep. 4
8:30-9:30

Introduction to Course NRSC 500
Dr. Tim O’Connor

9:30-10:30

Cell Biology of the Neuron
Dr. Tim O’Connor

 

 

Reading:

Powerpoint presentation
(PDF, 2010 version)

Alberts et al., Chap. 2

  • Biomolecules - lipids, amino acids, sugars, and nucleic acids
  • Hydrophobic effects and entropy - forces that fold proteins and make membranes
  • What is the cell membrane?
  • Properties of biomolecules and implications for neuronal function.




Sep. 6
8:30-10:30

Resting Membrane Potential
Dr. Lynn Raymond

 

 

Reading:

Kandel, Chap. 6 + Chap. 2 (for general introduction to neurobiology)

Lecture Hand-out (2013)

Problem Set (of 2011)

  • The ionic composition of the intracellular and extracellular spaces.
  • Electrochemical gradients.
  • Ohm's Law.
  • The Nernst equation.
  • Ionic basis of the resting membrane potential.
    • K+ permeability
    • impermeable intracellular anions
    • Na+/K+ ATPase

Students should bring their laptop computers and be prepared to connect to WIFI. We will be using the following website: www.metaneuron.org to demonstrate some of the concepts taught in the lecture.




Sep. 9
8:30-9:30

Electrophysiological Techniques
and
Molecular Biolology of Ion Channels
Dr. Marja Sepers
Dr. Lynn Raymond

 

 

Reading:

Lecture Hand-Out Part 1 (of 2011)

Voltage and Current Clamp Techniques (Lecture Notes, 2012)

Kandel, Chap. 5

  • Voltage and current clamp techniques, pitfalls and neuronal modelling.
  • An overview of the structure and function of voltage- and ligand-gated ion channels.




Sep. 11
8:30-10:30

Action Potential I
Dr. Jeremey Seamans

 

 

Reading:

Lecture Notes (of 2013)

Kandel, Chap. 6 + Chap. 7

  • Structure and function of Na+ channels.
  • Propagation of the action potential.
    • cable properties of neuronal membranes
    • myelination speeds action potential propagation
  • Recapitulation of resting membrane and action potentials.
  • Emerging role of dendrites
  • Computer simulation of the action potentital

Students should bring their laptop computers and be prepared to connect to WIFI. We will be using the following website: www.metaneuron.org to demonstrate some of the concepts taught in the lecture.




Sep. 13
8:30-10:30

Action Potential II
Dr. Jeremey Seamans

 

 

Reading:

Lecture Notes (2013)

Kandel, Chap. 6 + Chap. 7

  • The classic action potential is produced by the interplay of Na+ and K+ channels.
  • Na+ and K+ channels are voltage-dependent ionic channels.
    • selectivity
    • activation
    • inactivation
    • pharmacology
  • The voltage-clamp measures membrane current.
  • The Na+ current is self-sustaining.
  • Absolute and relative refractory periods.
  • The afterhyperpolarization and Ca++-dependent K+
    currents.

Students should bring their laptop computers and be prepared to connect to WIFI. We will be using the following website: www.metaneuron.org to demonstrate some of the concepts taught in the lecture.




Sep. 16
8:30-10:30

Molecular Approaches in Neurobiology
Dr. Ann Marie Craig

 

 

Reading:

Lecture Notes (2013)

I recommend a chapter in the textbook "Molecular Biology of the Cell" by Alberts, Johnson, Lewis, Raff, Roberts and Walter: 4th or 5th Ed, Chapter 8 "Manipulating Proteins, DNA and RNA"; or 3rd Ed, Chapter 7 "Recombinant DNA Technology".





Sep. 19
8:30-10:30

Voltage-Gated Ion Channels: K+ channels
Dr. Brian MacVicar

 

 

Reading:

Lecture Handout (2012)

Hille, Chapter 5

Jan, Y. N., and Jan, L. Y., Cloned potassium channels from eukaryotes and prokaryotes. Annu. Rev. Neurosci. 20: 91-123 (1997).

  • The role of K+ channels in neuronal function.
  • A brief survey of the growing list of K+ channels.
  • The A-type K+ channel as an example of a voltage-gated K+ channel.
  • The ATP-sensitive K+ channel as an example of a ligand gated K+ channel.




Sep. 20
8:30-10:30

Calcium Channels
Dr. Terry Snutch

 

 

Reading:

Lecture Notes (2012)

Textbook: Hille, chapter 4

Papers: Adams & Snutch, 2007;
Catterall et al., 2005;
Snutch, 2009;
Snutch et al., 2005; and
Trignham & Snutch, 2009.

  • A quick overview of voltage gated ion channels.
  • Calcium channels are diverse in structure, pharmacology, and function: HVA channels and LVA channels.
  • Basic structure of HVA channels: subunits and organization.
  • Map of the HVA family α1 subunit: important molecular features.
  • Calcium channels are topographically organized within the cell.
  • Disorders associated with calcium channels: pharmacology and genetics.
  • Questions, review of abstracts and discussion of labs doing cool calcium channel stuff




Sep. 23
8:30-10:30

Problem Set Workshop
Dr. Lynn Raymond &
Dr. Brian MacVicar

  • A chance to practice principles of neuronal electrical properties by solving problems.
  • Homework set is due at this lecture and will serve as starting point.



Sep. 25
8:30-10:30

Review I
Dr. Lynn Raymond

 

 

Reading:

Explanation of question 8

Listing of passive membrane property terms and units

  • Review of all lectures from September 7th through September 30th.  Students should come prepared with specific questions about the material covered during this time period.




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Learn more:

NRSC 500

NRSC 501

CPSC 532
(formerly
MECH 550)

STAT 540

Electives

Anatomy/Math

 

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