Chen S, Tran S, Sigler A, Murphy TH (2011)
Automated and quantitative image analysis of ischemic
dendritic blebbing using in vivo 2-photon microscopy data.
J Neurosci Methods
Sigler, A. and Murphy
T.H. (2010) In vivo two-photon imaging of fine
structure in the rodent brain: before, during and after
Stroke 41 (10 Suppl):
Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM,
Boyd JD, Ko RW, Vasuta OC, Graham RK, Hayden MR, Murphy TH, and Raymond LA (2010)
Early increase in
extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in
Huntington's disease mice.
Liu RR, and Murphy TH (2009) Reversible cyclosporine A sensitive mitochondrial
depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo. A two-photon imaging study.
J Biol Chem 284:36109-36117.
Li P and Murphy TH (2008) Two-photon imaging during prolonged middle cerebral artery
occlusion in mice reveals recovery of dendritic structure following reperfusion.
J Neurosci 28:11970-11979.
Brown CE, Wong C, and Murphy TH (2008) Rapid morphologic
plasticity of peri-infarct dendritic spines after focal ischemic stroke.
Murphy TH, Li P, Betts K, and Liu R (2008) Two-photon imaging of stroke onset in
vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage
to dendrites and spines.
J Neurosci 28:1756-1772.
Enright LE, Zhang S, and Murphy TH (2007) Fine mapping of the spatial relationship
between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts
within single neurons in vivo.
J Cereb Blood Flow Metab 27:1185-1200.
** Contains our
Zhang S and Murphy TH (2007) Imaging the impact of cortical
microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo.
PLoS Biol 5:e119.
Zhang S, Boyd J, Delaney K, and Murphy TH (2005)
Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia.
J Neurosci 25:5333-5338.
Winship IR and Murphy TH (2009)
Re-mapping the somatosensory cortex brain after stroke: insight from imaging the synapse to network.
The Neuroscientist 15:507-524.
Sigler A, Mohajerani MH, and Murphy TH (2009) Imaging
rapid redistribution of sensory-evoked depolarization through existing cortical pathways
after targeted stroke in mice.
Proc Natl Acad Sci U S A. 106: 11759-64.
Brown CE, Aminoltejari K, Erb H,
Winship I, and Murphy TH (2009) In vivo voltage sensitive dye imaging in adult
mice reveals that somatosensory maps lost to stroke are replaced over weeks by new structural
and functional circuits with prolonged modes of activation within both the peri-infarct
zone and distant sites.
J. Neurosci. 2009 29:1719-1734. **Contains our
Brown CE and Murphy TH (2008) Livin' on the edge:
imaging dendritic spine turnover in the peri-infarct zone during ischemic stroke and recovery.
Neuroscientist 14: 139-146
Brown CE, Li P, Boyd JD, Delaney KR, and Murphy TH (2007)
Extensive turnover of dendritic spines and vascular remodeling in cortical tissues recovering from stroke.
J Neurosci 27:4101-4109.
Synaptic plasticity and basic circuit properties.
MurphyT.H. (2012) Voltage-Sensitive Dye Imaging Reveals Dynamic
Spatiotemporal Properties of Cortical Activity after
Spontaneous Muscle Twitches in the Newborn Rat.
2012 Aug 8;32(32):10982-9
D.H. M.H. Mohajerani, Boyd J., LeDue J., Chen S., and Murphy
T.H.(2012)In vivo large-scale cortical mapping using
channelrhodopsin-2 stimulation in transgenic mice reveals
asymmetric and reciprocal relationships between cortical
areas.Front. Neural Circuits6:11. doi:
N.A., Murphy T.H & Illes J.(2012) Incidental findings in
neuroimaging research:a framework for anticipating the next frontier.Journal of
Empirical Research on Human Research Ethics, DOI:
Scott, N., Murphy, T.H. Hemodynamic
responses evoked by selective neuronal stimulation via
channelrhodopsin-2 are independent of intracortical ionotropic
excitatory synaptic transmission.
PLoS ONE 7(1): e29859. doi:10.1371
Takahashi H, Arstikaitis P, Prasad T,
Bartlett TE, Wang YT, Murphy TH, Craig AM (2011) Postsynaptic
TrkC and presynaptic PTPsigma function as a bidirectional
excitatory synaptic organizing complex.
Arstikaitis P, Gauthier-Campbell C,
Huang K, El-Husseini A, Murphy TH (2011) Proteins that promote
filopodia stability, but not number, lead to more
PLoS One 6:e16998.
Mohajerani MH, McVea DA, Fingas M, and Murphy TH (2010)
Mirrored bilateral slow-wave cortical activity within local circuits revealed by fast
bihemispheric voltage-sensitive dye imaging in anesthetized and awake mice.
J Neurosci 30:3745-51.
Harrison TC, Sigler A, and Murphy TH. (2009)
Simple and cost-effective hardware and software for functional brain mapping using Intrinsic
Optical Signal imaging.
J Neurosci Methods 182:211-218; also see:
Ayling OG, Harrison TC, Boyd JD,
Goroshkov A, and Murphy TH. (2009) Automated light-based mapping of motor cortex by
photoactivation of channelrhodopsin-2 transgenic mice.
Nat Methods 6:219-224.
Supported in part by the Estate of Erika W. White.
The purpose of this fund is to support research into the medical use of laser technology.
Awatramani GB, Boyd JD, and Delaney KR,
Murphy TH (2007) Effective release rates at single rat Schaffer collateral-CA1 synapses
during sustained theta-burst activity revealed by optical imaging.
J Physiol 582:583-595.
Winship IR, Plaa N, and Murphy TH (2007)
Rapid astrocyte calcium signals correlate with neuronal activity and onset of the hemodynamic response in vivo.
J Neurosci 27:6268-6272.
Gauthier-Campbell C, Carolina Gutierrez-Herrera R, Huang K,
Levinson JN, Murphy TH, Kilimann MW, Sala C, Colicos MA, and El-Husseini A (2008)
Paralemmin-1, a Modulator of filopodia induction is required for spine maturation.
Mol Biol Cell 19:2026-2038.
Liu Z, Otsu Y, Vasuta C, Nawa H, and Murphy TH (2007)
Action-potential-independent GABAergic tone mediated by nicotinic stimulation
of immature striatal miniature synaptic transmission.
J Neurophysiol 98:581-593.
Liu Z, Ren J, and Murphy TH (2003)
Decoding of synaptic voltage waveforms by specific classes high threshold calcium channels.
J Physiol 553:473-488;
Otsu Y and Murphy TH (2003)
Miniature transmitter release: Accident of nature or careful design?
Sci STKE 2003(211):pe54.
Mackenzie PJ, Kenner GS, Prange O, and Murphy TH (2000)
Vesicle number does not predict postsynaptic measures of miniature
synaptic activity frequency in cultured cortical neurons.
Neuroscience 98:1-7. **Contains our
Mackenzie PJ, Kenner GS, Prange O, Shayan H, Umemiya M, and Murphy
TH (1999) Ultrastructural correlates of quantal synaptic function at single CNS synapses.
J Neurosci 19:RC13.
Nakazawa H and Murphy TH. (1999)
Activation of nuclear calcium dynamics by synaptic stimulation in cultured cortical neurons.
J Neurochem 73:1075-1083.
Umemiya M, Senda M, and Murphy TH (1999)
Behavior of NMDA and AMPA receptor mediated miniature excitatory synaptic currents at
synapses identified by calcium imaging.
J Physiol (Lond). 521:113-22.
Mackenzie PJ, Umemiya M, and Murphy TH (1996)
Ca2+ imaging of CNS axons in culture indicates reliable coupling between
single action potentials and distal functional release sites.
Neuron 16:783-795. **Contains our
Murphy TH, Baraban JM, and Wier WG (1995)
Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in
Murphy TH, Baraban JM, Wier WG, and Blatter LA (1994)
Visualization of quantal synaptic transmission by dendritic calcium imaging.
Murphy TH, Blatter LA, Wier WG, and Baraban JM (1993)
Rapid communication between neurons and astrocytes in primary cortical cultures.
J Neurosci 13:2672-2679.
Murphy TH, Worley PF, and Baraban JM (1991)
L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes.
Layton R.H., Payapilli J.,
Ma T., Murphy T.H., Smirnova N., Langley B.C., Sultana R.,
Butterfield D.A., Santagata S., Gazaryan I., Bell G.W., and
Ratan R.R. (2010) Refining the “peroxide code”: spatial,
temporal and quantitative regulation of hydrogen peroxide in
astrocytes induces non-cell-autonomous protection of neurons
via a novel Nrf-2-independent pathway. PNAS 107(40):17385-90,
Shih AY, Erb H, and Murphy TH (2007)
Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cells.
J Neurochem 101:109-119.
Shih AY, Erb H, Sun X, Toda S, Kalivas PW, and Murphy TH (2006)
Cystine/glutamate exchange modulates glutathione supply for neuroprotection
from oxidative stress and cell proliferation.
J Neurosci 26:10514-10523.
Sun X, Shih AY, Johannssen HC, Erb H, Li P, and Murphy TH (2006)
Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering
in developing neurons and cells at the cerebrospinal fluid and blood-brain interface.
J Biol Chem 281:17420-17431.
Shih AY, Li P, and Murphy TH (2005a) A small-molecule-inducible
Nrf2-mediated antioxidant response provides effective
prophylaxis against cerebral ischemia in vivo.
J Neurosci 25:10321-10335.
Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH (2005b)
Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.
J Biol Chem 280:22925-22936.
Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, Erb H, Johnson JA, Murphy TH
(2003) Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia
potently protects neurons from oxidative stress.
J Neurosci 23:3394-3406.
Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT (1989)
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport
leading to oxidative stress.